Fused Deposition Modeling Printed PLA/Nano β-TCP Composite Bone Tissue Engineering Scaffolds for Promoting Osteogenic Induction Function

Oct 23, 2023International journal of nanomedicine

3D-Printed PLA and Nano β-TCP Composite Scaffolds for Supporting Bone Tissue Growth

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

The -printed PLA/nano-β-TCP composite scaffold with a ratio of 7:3 demonstrated superior biological performance for bone repair.

The scaffolds exhibited personalized porosity and shape, which are important for effective bone regeneration.
In vitro and in vivo evaluations showed that the composite scaffolds had enhanced osteogenic ability compared to pure PLA.
Biocompatibility assessments indicated that the PLA/nano-β-TCP scaffolds are suitable for use in biological environments.
The combination of biodegradable PLA and bioactive nano-β-TCP ceramics improved the overall performance of the scaffolds for bone repair.

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PURPOSE: Large bone defects caused by congenital defects, infections, degenerative diseases, trauma, and tumors often require personalized shapes and rapid reconstruction of the bone tissue. Three-dimensional (3D)-printed bone tissue engineering scaffolds exhibit promising application potential. (FDM) technology can flexibly select and prepare printed biomaterials and design and fabricate bionic microstructures to promote personalized large bone defect repair. FDM-3D printing technology was used to prepare polylactic acid (PLA)/nano β-tricalcium phosphate (TCP) composite bone tissue engineering scaffolds in this study. The ability of the bone-tissue-engineered scaffold to repair bone defects was evaluated in vivo and in vitro.

METHODS: PLA/nano-TCP composite bone tissue engineering scaffolds were prepared using FDM-3D printing technology. The characterization data of the scaffolds were obtained using relevant detection methods. The physical and chemical properties, biocompatibility, and in vitro osteogenic capacity of the scaffolds were investigated, and their bone repair capacity was evaluated using an in vivo animal model of rabbit femur bone defects.

RESULTS: The FDM-printed PLA/nano β-TCP composite scaffolds exhibited good personalized porosity and shape, and their osteogenic ability, biocompatibility, and bone repair ability in vivo were superior to those of pure PLA. The merits of biodegradable PLA and bioactive nano β-TCP ceramics were combined to improve the overall biological performance of the composites.

CONCLUSION: The FDM-printed PLA/nano-β-TCP composite scaffold with a ratio of 7:3 exhibited good personalized porosity and shape, as well as good osteogenic ability, biocompatibility, and bone repair ability. This study provides a promising strategy for treating large bone defects.

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Increase in Osteogenic Activity

Osteogenic marker activity measured at day 7.

Higher than pure PLA

Bone Tissue Volume Ratio

Comparison of bone tissue volume in rabbit models.

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Fused Deposition Modeling Printed PLA/Nano β-TCP Composite Bone Tissue Engineering Scaffolds for Promoting Osteogenic Induction Function

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