Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats

Nov 13, 2019International journal of biological macromolecules

Ganoderma lucidum polysaccharides may restore gut bacteria and metabolism in type 2 diabetic rats

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Abstract

Administration of Ganoderma lucidum polysaccharides (GLP) resulted in significant decreases in fasting blood glucose and insulin levels in type 2 diabetes mellitus (T2DM) rats.

GLP treatment reduced the abundance of harmful bacteria, including Aerococcus and Ruminococcus.
In contrast, GLP increased beneficial bacteria such as Blautia and Bacteroides.
GLP may restore disrupted metabolism of amino acids, carbohydrates, inflammatory substances, and nucleic acids in the gut microbiota.
Metabolomic analysis showed that metabolic changes aligned with the effects of GLP on gut bacteria.

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Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti-diabetic effects. In order to unravel the underlying mechanism of its anti-diabetic effect, this study examines the effects of GLP on gut microbiota composition and functions in type 2 diabetes mellitus (T2DM) status. In this study, the effects of GLP on the gut microbiota and fecal metabolites in high-fat diet and streptozotocin-induced T2DM rats were examined by 16S rDNA sequencing andH NMR profiling. As a result, administration of GLP led to significant decreases in the levels of fasting blood glucose and insulin. Moreover, GLP treatment reduced the abundance of harmful bacteria, such as Aerococcus, Ruminococcus, Corynebactrium and Proteus, and increased the level of Blautia, Dehalobacterium, Parabacteroides and Bacteroides. The PICRUSt analysis indicated that GLP could restore the disturbed amino acids metabolism, carbohydrates metabolism, inflammatory substances metabolism and nucleic acid metabolism of gut bacterial community in T2DM rats and most metabolic changes observed by metabolomics analysis were consistent with these consequences. Taken collectively, GLP can restore the disordered gut microbiota of T2DM rats to a normal level and modify metabolites of the host to realize its antidiabetic effects. 1

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