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A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules
Predicting How Slower Stomach Emptying Affects Small Molecule Drug Levels
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Abstract
Dulaglutide is associated with a delay in gastric emptying, which may influence the of orally administered medications.
- A population pharmacokinetic model estimated that dulaglutide's effect on gastric emptying is dose-dependent.
- The modeling approach was able to reproduce observed interactions between dulaglutide and other drugs at low doses.
- At a dose of 1.5 mg, dulaglutide showed no clinically relevant impact on the pharmacokinetics of small molecules.
- Predictions for drug-drug interactions were made for a 4.5 mg dose of dulaglutide, indicating similar outcomes.
- The findings suggest that modeling can enhance the understanding of potential drug interactions related to gastric emptying.
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Key numbers
5.66 h
Gastric Mean Residence Time
Mean residence time for gastric emptying after 4.5 mg dulaglutide.
0.93 (0.86, 1.00)
AUC Ratio for Acetaminophen
AUC ratio when co-administered with 4.5 mg dulaglutide.