Herbal combination of Gastrodia elata and Acorus tatarinowii reduces seizures and brain damage in epilepsy rats by affecting cell cleanup and inflammation pathways

Temporal lobe epilepsy (TLE) is the most common drug-resistant focal epilepsy.

• TLE progression may be closely linked to mitochondrial dysfunction.
• Neuroinflammation is associated with the advancement of TLE.
• Neuronal injury could play a role in the severity of TLE.
• The herbal pair Gastrodia elata and Acorus tatarinowii is traditionally used for convulsive disorders.
• The anti-epileptic mechanisms of this herbal pair remain unclear.

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