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GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates
Blocking GDF8 and activin A prevents muscle loss caused by GLP-1 and boosts fat loss in obese male mice and primates
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Abstract
Dual blockade of and may prevent muscle loss and could increase muscle mass when using glucagon-like peptide-1 receptor agonists.
- Glucagon-like peptide-1 receptor agonists are linked to significant muscle loss due to mechanisms that conserve energy during periods of reduced caloric intake.
- Activation of type II activin receptors is associated with a reduction in muscle mass.
- Blocking GDF8 and activin A, which are key ligands of activin receptors, may counteract muscle loss.
- In studies with obese mice and non-human primates, dual blockade resulted in muscle preservation and an increase in muscle mass.
- Muscle preservation was also correlated with enhanced fat loss and metabolic benefits.
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Key numbers
10 of 10
Increase in Lean Mass
All monkeys in the treatment group showed preserved or increased lean mass.
25%
Fat Mass Loss
Fat mass loss observed in treated monkeys over the study duration.