Research trends and advanced applications of gelatin in cartilage tissue engineering: a combined bibliometric and comprehensive review

Nov 11, 2025Journal of materials chemistry. B

Research trends and new uses of gelatin in cartilage tissue repair

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Abstract

A total of 1276 publications on gelatin-based cartilage tissue engineering were analyzed from 2005 to 2025.

  • Three distinct developmental phases were identified: foundational materials development (2005-2012), stem cell regulation research (2013-2020), and the rise of smart-responsive 4D bioprinting technologies (2021-2025).
  • Four core research clusters included advancements in biomaterials, control of stem cell environments, growth factor delivery innovations, and 3D/4D printing integration.
  • The theme of 'stem cell differentiation' consistently emerged as a central focus throughout the analyzed literature.
  • China produced the highest number of publications (478 articles), but exhibited lower citation rates compared to the Netherlands and the United States.
  • Strategic recommendations were proposed to address clinical translation challenges, including standardized evaluation frameworks and enhanced collaboration between regions.

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