Gellan gum and carboxymethyl chitosan-based acid-responsive hydrogels modulate the ROS-macrophage axis to expedite burn wound healing

The COGS hydrogel demonstrates exceptional mechanical strength and dynamic regulation of reactive oxygen species (ROS) and macrophage activity.

• COGS hydrogel uses a combination of carboxymethyl chitosan, oxidized gellan gum, and gentamicin sulfate to enhance burn treatment.
• In vitro tests indicate improved hemostatic performance and controlled release of antibiotics.
• In vivo results show that the hydrogel facilitates a two-phase therapeutic action to combat infection and promote tissue regeneration.
• The hydrogel initially releases gentamicin to target pathogens and later modulates ROS levels to influence macrophage behavior.
• This approach may balance inflammatory responses and accelerate tissue healing while minimizing organ toxicity associated with gentamicin.

AI simplified