Gene activity in healing diabetic rat skin wounds treated with chitosan and curcumin nanoparticles in a special gel

The curcumin-loaded chitosan nanoparticles embedded in hydrogel showed a remarkable swelling capacity of 2075% within the first 15 minutes.

• The H/CS-CUR hydrogel demonstrated sustained release and superior antibacterial activity compared to standard hydrogel.
• In vivo studies indicated that H/CS-CUR treatment accelerated wound closure in diabetic rats compared to the control group.
• Higher levels of IGF-1 and TGF-β1 were observed in the H/CS-CUR group, suggesting enhanced immune response and improved wound healing.
• The H/CS-CUR group exhibited increased epidermal thickness, dermal thickness, granulation tissue formation, and vessel density.
• Decreased IL-6 expression in the H/CS-CUR group indicated significant anti-inflammatory effects.

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