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Evaluation of gene expression levels in diabetic rat skin wound healing treated with chitosan/curcumin nanoparticles-loaded sodium alginate/chitosan hydrogels
Gene activity in healing diabetic rat skin wounds treated with chitosan and curcumin nanoparticles in a special gel
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Abstract
The curcumin-loaded chitosan nanoparticles embedded in hydrogel showed a remarkable swelling capacity of 2075% within the first 15 minutes.
- The H/CS-CUR hydrogel demonstrated sustained release and superior antibacterial activity compared to standard hydrogel.
- In vivo studies indicated that H/CS-CUR treatment accelerated wound closure in diabetic rats compared to the control group.
- Higher levels of IGF-1 and TGF-β1 were observed in the H/CS-CUR group, suggesting enhanced immune response and improved wound healing.
- The H/CS-CUR group exhibited increased epidermal thickness, dermal thickness, granulation tissue formation, and vessel density.
- Decreased IL-6 expression in the H/CS-CUR group indicated significant anti-inflammatory effects.
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