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Mini review: Gene therapy targets for aging-associated diseases
Gene therapy targets for diseases linked to aging
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Abstract
Gene therapy approaches may intervene in aging mechanisms and treat age-associated diseases.
- Gene therapeutic strategies can target neurodegenerative, cardiovascular, metabolic, and ophthalmological disorders.
- Specific aging mechanisms such as DNA damage, telomere shortening, mitochondrial dysfunction, and chronic inflammation can potentially be addressed.
- Therapeutic targets include reactivating telomerase through TERT overexpression for genomic stability and using KLOTHO for anti-inflammatory effects.
- Metabolic regulation may involve SIRT family genes and FoxO3, while protein homeostasis could be influenced by APOE variants.
- Emerging methods such as GDF11 for tissue regeneration, senolytics for removing senescent cells, and epigenetic reprogramming could offer rejuvenation.
- The effects of these interventions are context-dependent and tailored to specific diseases, with varying benefit-risk profiles.
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