Association between genetic variants of the clock gene and obesity and sleep duration

Nov 11, 2015Journal of physiology and biochemistry

Links between clock gene differences, obesity, and sleep length

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Abstract

Six CLOCK gene variants are associated with sleep duration.

  • Obesity is influenced by both genetic and environmental factors related to lifestyle.
  • Reduced sleep is linked to an increased body mass index (BMI).
  • Three CLOCK gene variants are associated with energy intake variables.
  • Eight common CLOCK gene variants are associated with obesity.
  • The most researched CLOCK variant is rs1801260, primarily studied in European populations.
  • Identifying at-risk CLOCK genotypes may help determine susceptibility to overeating when sleep is short.

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