Links between clock gene differences, obesity, and sleep length

Six CLOCK gene variants are associated with sleep duration.

• Obesity is influenced by both genetic and environmental factors related to lifestyle.
• Reduced sleep is linked to an increased body mass index (BMI).
• Three CLOCK gene variants are associated with energy intake variables.
• Eight common CLOCK gene variants are associated with obesity.
• The most researched CLOCK variant is rs1801260, primarily studied in European populations.
• Identifying at-risk CLOCK genotypes may help determine susceptibility to overeating when sleep is short.

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