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Abstract
Essence
A polygenic Circadian Imbalance Index was linked to metabolic, cardiovascular, and mood-related traits in UK Biobank participants of European ancestry.
Evidence
This was a GWAS of CII in 312,935 European ancestry UK Biobank participants, with gene-overlap, polygenic score, genetic correlation, phenome-wide, and Mendelian randomization analyses.
Caveat
The findings depend on a composite index and largely European ancestry biobank data, and Mendelian randomization signals do not establish all mechanisms or clinical utility.
Simplified
Circadian Biology