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Genome wide association study of a Circadian Imbalance Index in 312,935 European ancestry UK Biobank participants identifies loci related to diabetes, mood and myocardial infarction
Genetic links to daily rhythm imbalance related to diabetes, mood, and heart attack in over 300,000 Europeans
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Abstract
In a genome-wide association study of 312,935 participants, 27 genetic loci associated with the Circadian Imbalance Index (CII) were identified.
- CII integrates factors such as chronotype, sleep duration, neuroticism, caffeine intake, and vitamin D.
- Gene-overlap analyses revealed shared genetic architecture with components of CII.
- A polygenic score for CII showed associations with type 2 diabetes, major depressive disorder, and obesity.
- Genetic correlations suggested links between CII and insomnia, mood symptoms, body mass index, type 2 diabetes, coronary artery disease, and myocardial infarction.
- Mendelian randomization indicated potential causal effects of CII on type 2 diabetes, mood swings, and myocardial infarction.
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