Daily gene activity patterns in brain support cells show cell-type and disease-specific changes with amyloid buildup or aging

Glial circadian gene expression differed by cell type and was reprogrammed by amyloid pathology or aging in mouse cortex.

This mouse translatome study used translating ribosome affinity purification to profile circadian expression in astrocytes, microglia, and bulk cortex under healthy, amyloid-plaque, and aging conditions.

The evidence comes from mouse cortex and gene-expression and functional assays, so it does not directly show human Alzheimer's disease outcomes.