GLP-1 receptor agonist-associated eosinophilic duodenitis presenting as a bowel obstruction : a case report and literature review
Bowel obstruction linked to inflammation in the small intestine caused by a diabetes drug: a case report and review
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Abstract
A rare adverse effect of oral semaglutide, severe gastric stasis, was observed in a patient treated for type 2 diabetes and obesity.
- The patient experienced progressive upper gastrointestinal symptoms, leading to faecal vomiting.
- Endoscopic examination showed significant eosinophilic infiltration in the duodenum.
- This case is the first to link semaglutide to eosinophil-driven duodenitis causing mechanical bowel obstruction.
- Clinicians should be aware of rare but serious gastrointestinal effects associated with GLP1 receptor agonists.
- Early recognition of symptoms and consideration of eosinophilic gastrointestinal disease may aid in diagnosis and management.
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