Brain pathways of GLP-1 signals in controlling hunger and reward related to substance use

GLP-1 acts as a state-dependent signal that suppresses appetite and promotes satiety.

• GLP-1-producing neurons in the brainstem connect to various brain regions involved in metabolism and reward.
• The widespread presence of GLP-1 receptors suggests their role in integrating motivated behavior with physiological states.
• GLP-1R agonists may engage central GLP-1 receptors through specific brain areas to reduce feeding and drug-seeking behaviors.
• Preclinical and clinical evidence supports the effectiveness of GLP-1R agonists in treating obesity and metabolic disorders.
• There is potential for GLP-1R agonists to be used in treating disorders related to maladaptive reward behaviors, such as substance use disorders.

Simplified