Glucagon‐like peptide‐1 receptor agonist treatment reduces body weight and improves glycaemic outcomes in patients with concurrent overweight/obesity and type 1 diabetes: A systematic review and meta‐analysis

🥉 Top 5% JournalDec 3, 2025Diabetes, obesity & metabolism

GLP-1 Treatments Help Weight Loss and Blood Sugar Control in Overweight Type 1 Diabetes Patients

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Abstract

GLP-1 receptor agonist treatment was associated with a body weight reduction of 4.31 kg in individuals with type 1 diabetes and overweight or obesity.

Treatment with GLP-1 receptor agonists resulted in a decrease in HbA1c levels by 0.25%.
Insulin dosage was reduced by 9.24 U/day on average when GLP-1 receptor agonists were used.
Semaglutide was identified as achieving the greatest reductions in body weight and glycemic levels.
An increase in hypoglycemic episodes was observed (odds ratio = 1.34), while hyperglycemic episodes decreased (odds ratio = 0.69).
Gastrointestinal adverse events, such as nausea and vomiting, were more common with GLP-1 receptor agonist treatment, but serious adverse events did not increase.

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AIMS: This systematic review and meta-analysis evaluated the long-term efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as adjunctive therapies for individuals with type 1 diabetes (T1D) and overweight or obesity.

MATERIALS AND METHODS: A literature search was conducted in June 2023 and updated in June 2025. Eligible studies included adults with T1D, body mass index ≥25 kg/m, and GLP-1RA treatment alongside insulin for ≥12 weeks. Changes in body weight, HbA1c, and insulin dose were expressed as mean differences (MDs) with 95% confidence intervals (CIs). Safety outcomes were assessed using odds ratios (ORs) with 95% CIs. Data were pooled using random-effects models. 2

RESULTS: Exactly 13 studies met the inclusion criteria. GLP-1RA treatment was associated with a body weight reduction of 4.31 kg (95% CI: 3.61-5.00 kg) and a HbA1c reduction of 0.25% (95% CI: 0.18-0.32%). Across all studies, insulin dosage was reduced by 9.24 U/day (95% CI: 7.04-11.45 U/day). Subgroup analysis identified that semaglutide achieved the greatest reductions in all outcome measures. Hypoglycaemic episodes were increased (OR = 1.34; 95% CI: 1.02-1.76), while hyperglycaemic episodes decreased (OR: 0.69, 95% CI: 0.56-0.87). Gastrointestinal adverse events, including nausea and vomiting, were significantly more frequent with GLP-1RA treatment, though no increase in serious adverse events was observed.

CONCLUSIONS: GLP-1RAs are effective for body weight reduction and glycaemic improvement in individuals with T1D and overweight/obesity, with acceptable safety profiles. These findings provide evidence that GLP-1RAs can be effectively and safely used as adjunctive therapy to insulin in people with T1D, but additional robust randomised clinical trials are needed.

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