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Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Key effects of glucagon-like peptide 1 on blood sugar control in mice lacking GLP-1 receptors
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Abstract
Heterozygous GLP-1R +/- mice show an abnormal glycemic response to oral glucose challenge with reduced circulating levels of glucose-stimulated insulin.
- GLP-1 is involved in controlling blood glucose through multiple mechanisms, including insulin and glucagon secretion and gastric emptying.
- GLP-1R +/- mice exhibited a distinct glycemic response compared to wild-type mice, indicating a gene dosage effect on GLP-1's incretin action.
- No significant changes in fasting and postabsorptive glucagon levels were observed in GLP-1R -/- or +/- mice.
- Pancreatic insulin mRNA levels were similar in both wild-type and GLP-1R -/- mice, despite GLP-1's role in stimulating proinsulin gene transcription.
- Whole-body glucose utilization was comparable in wild-type and GLP-1R -/- mice under various insulin conditions.
- Only the incretin effect on pancreatic beta-cells appears essential for regulating glucose homeostasis in vivo.
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