Drugs

Glucagon-like peptide-1 receptor agonist linked to liver disease progression and alcohol-related hospital visits in people with alcohol use disorder and diabetes

Updated

Abstract

Use of GLP-1 receptor agonists resulted in progression to cirrhosis in 6.6% of users compared to 6.0% of dipeptidyl peptidase-4 inhibitor users.

  • In a matched cohort of 7302 patients, the odds of developing cirrhosis after using GLP-1RA were similar to those using DPP4i.
  • Alcohol-related hospital admissions occurred in 1.4% of GLP-1RA users versus 1.7% of DPP4i users.
  • The odds ratio for alcohol-related hospital admission indicated no significant difference between the two groups.
  • Findings suggest that GLP-1RA may not provide a beneficial effect on liver disease progression or hospital admissions related to alcohol use.

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Funding

Competing interests

Declarations. Funding: Resources of the Orlando VA Medical Center were used to conduct the study. This work was supported, in part or in whole, by HCA Healthcare and/or an HCA Healthcare affiliated entity. Role of Sponsor: None. Conflict of Interest/Disclosure: The authors declare that they do not have a financial conflict of interest related to this work. Disclaimer: The views expressed herein are those of the authors and do not reflect the official policy or position of the Veterans Health Administration, or the US Government or any of its affiliated entities. Some of the authors are employees of the US government. This work was prepared as part of their official duties and, as such, there is no copyright to be transferred. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities. Data Availability Statement: Data are stored in the VA Informatics and Computing Infrastructure (VINCI), the operational platform for health services research at the Veterans Healthcare Administration (VHA). VINCI acts as data steward for VHA Data Systems. Data in VINCI cannot be copied, transferred, or printed. Access to data by other researchers is possible following VINCI protocols, as described in the VINCI Central website: http://vaww.vinci.med.va.gov/VinciCentral . Ethics Approval: The Orlando VA institutional review board approved the study. Consent to Participate: The Orlando VA institutional review board waived the need for participants’ informed consent since only preexisting deidentified data were used. Consent for Publication: Not applicable. Author Contributions: FA: study concept and design, interpretation of data, and drafting of the manuscript. SK: study concept and design, drafting of the manuscript, and critical revision of the manuscript for important intellectual content. VK: study concept and design, interpretation of data, and critical revision of the manuscript for important intellectual content. MK: study concept and design, interpretation of data, critical revision of the manuscript for important intellectual content, and study supervision. IM: study concept and design, acquisition of data along with statistical analysis, interpretation of data, critical revision of the manuscript for important intellectual content, and study supervision. Code Availability: Not applicable.
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