Effects of glucagon‐like PEPTIDE‐1 receptor agonists on incidence of hepatocellular carcinoma and liver decompensation in patients with diabetes: A systematic review and META‐analysis

Feb 12, 2025European journal of clinical investigation

Glucagon-like peptide-1 drugs and their link to liver cancer and liver failure in people with diabetes: A combined study review

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Abstract

GLP-1 receptor agonist use is associated with a 58% reduction in hepatocellular carcinoma risk among over 641,377 patients.

  • Patients with cirrhosis may experience greater benefits from GLP-1 receptor agonists regarding HCC risk reduction.
  • A trend towards reduced liver decompensation risk was noted, but this was not statistically significant.
  • The findings suggest a potential role for GLP-1 receptor agonists in strategies for HCC risk assessment and prevention.

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