Annals of internal medicineJul 13, 2026

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Blood Flow Blockage in the Optic Nerve: A Target Trial Emulation

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Jul 14, 2026

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may be linked to nonarteritic anterior ischemic optic neuropathy (NAION), which accounts for approximately 75% of ischemic optic neuropathy cases in adults.

Limited data exist on the relationship between GLP-1RAs and NAION.
NAION is a prevalent form of ischemic optic neuropathy in adults.
The association between GLP-1RAs and NAION has not been extensively evaluated.

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Competing interests

No competing interests reported.

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