Glucagon-like Peptide-1 Receptor Agonists and Their Effects on Reproductive Health: What Current Evidence Shows

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may impact reproductive health, particularly concerning weight loss and fertility.

• Tirzepatide has been shown to delay gastric emptying, potentially affecting the absorption of oral contraceptives.
• Other GLP-1RAs do not appear to have clinically significant interactions with oral contraception.
• Weight loss and metabolic benefits associated with GLP-1RAs may improve fertility outcomes.
• Data on the effects of GLP-1RAs during pregnancy and lactation remain limited, indicating a need for further research.
• A review of current literature highlights the importance of considering reproductive health when prescribing GLP-1RAs.

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