Effects of glucagon-like peptide-1 receptor agonists on upper endoscopy in diabetic and nondiabetic patients

May 1, 2024Gastrointestinal endoscopy

Effects of glucagon-like peptide-1 receptor agonists on upper digestive tract examinations in people with and without diabetes

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Abstract

GLP-1 receptor agonist use is associated with a 4-fold increase in the retention of gastric contents during EGD procedures.

  • Use of GLP-1 receptor agonists is linked to 4-fold higher rates of aborted EGD.
  • Patients on GLP-1 receptor agonists are twice as likely to require repeat EGD.
  • Delayed gastric emptying may impact the adequacy of EGD, regardless of diabetes status.
  • Dose adjustments of GLP-1 receptor agonists may be necessary to enhance the safety of EGD procedures.

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