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Science with Seymour Levine: on glucocorticoid action from birth to senescence
Glucocorticoid Hormone Effects Throughout Life, from Birth to Old Age
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Abstract
Cessation of glucocorticoid receptor expression in the suprachiasmatic nucleus may explain phase dissociation of the master pacemaker from glucocorticoid-driven cellular clocks.
- Innervation by the optic nerve around postnatal day 12 is associated with changes in glucocorticoid receptor expression.
- Maternal care is linked to protective effects against harmful influences and may help infants develop stress coping mechanisms.
- Distinct components of maternal care, such as feeding and tactile interaction, can differentiate the activation of stress response systems in pups.
- Maternal separation for 24 hours at postnatal day 3 may lead to cognitive aging that ranges from senility to excellence.
- Glucocorticoid action during early life potentially amplifies individual differences in stress coping and adaptation throughout life.
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