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Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome
Stress-related irritable bowel syndrome linked to disrupted body clock control by stress hormone receptors
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Abstract
Stress-induced changes in glucocorticoids are associated with chromatin circadian misalignment in the colon epithelium.
- Significantly decreased core circadian gene expression was observed in the colon epithelium of stressed BALB/c mice, similar to patterns seen in IBS patients.
- Stress reduced glucocorticoid receptor binding at the promoter E-box, indicating a potential mechanism by which stress affects circadian regulation.
- Alterations in glucocorticoid receptor binding were noted at E-box sites along the chromatin, which may impact circadian gene regulation.
- Stress modified the three-dimensional chromatin structure, suggesting that glucocorticoids play a role in remodeling chromatin in response to stress.
- Intestinal deletion of the glucocorticoid receptor abolished stress-induced transcriptional changes linked to IBS phenotypes in the mouse model.
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