Glucose deprivation impairs lipid tolerance related to mitophagy disorder in cardiomyocytes

Glucose deprivation following high glucose and lipid treatment significantly increased cardiomyocyte susceptibility to injury.

• Brief exposure to high glucose and lipid levels maintained cardiomyocyte viability and enhanced the process of removing damaged mitochondria.
• Following glucose deprivation after high glucose and lipid treatment, cell viability was reduced, and apoptosis increased.
• Mitochondrial dysfunction was observed, characterized by disrupted mitochondrial structure, depolarization, and decreased energy production.
• Impairment of the mitochondrial removal process was noted in cells subjected to glucose deprivation after high glucose and lipid treatment.
• Treatment with the mitophagy activator urolithin A reversed the adverse effects on cardiomyocytes.

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