Journal of diabetes investigation

Is increased glicentin release after gastric bypass linked to better blood sugar control from higher insulin in a type 2 diabetes patient without remission after sleeve gastrectomy?

Updated

Abstract

A morbidly obese patient with type 2 diabetes showed improved hyperglycemia after surgery following initial failure of diabetes remission from .

  • The patient experienced a significant improvement in blood sugar levels post-surgery.
  • Passage failure of solid food intake at the gastric angle resolved after the revision surgery.
  • Insulin and secretion increased notably after Roux-en-Y gastric bypass compared to after sleeve gastrectomy.
  • Minor changes were observed in the secretion of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) during the oral glucose tolerance test after Roux-en-Y gastric bypass.
  • Further research is necessary to determine if the increased glicentin secretion is related to enhanced insulin secretion.

Simplified

Key numbers

4.7 kg
Body Weight Decrease
Weight change from 78.7 kg post- to 74 kg post-.
4.1%
Improvement
changed from 11.4% post- to 7.3% post-.
58.5 μU/mL
Insulin Level Increase
Insulin level at 30 minutes post- during .

Full Text

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Funding

Competing interests

The authors declare no conflict of interest in this study. Approval of the research protocol: The case study is a part of clinical studies on the differences in postprandial glucose and triglyceride excursions in severely obese patients between before and after LSG shown in Ref. . The study was conducted according to the guidelines of the Declaration of Helsinki and was approved by the Institutional Review Board of Kusatsu General Hospital (protocol no. 2017‐0317‐05, date of registry: 24 March, 2017). Note that the name of Kusatsu General Hospital was changed to Omi Medical Center on October 1, 2021. Informed consent: Written informed consent to participate in the study and to publish the paper has been obtained. Registry and the registration no. of the study: This study was not related to an intervention study. Therefore, we did not apply the registration of the protocol. Animal study: N/A.
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