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Abstract
Among 118,341 T2DM patients using metformin, cardiovascular risk was lower in users of sodium-glucose cotransporter-2 inhibitors, dipeptidyl peptidase-4 inhibitors, and glucagon-like peptide 1 agonists compared to sulfonylurea users.
- During a median follow-up of 10 months, users of SGLT-2 inhibitors had a 39% lower risk of cardiovascular events compared to sulfonylurea users.
- Dipeptidyl peptidase-4 inhibitor users experienced a 21% reduction in cardiovascular risk compared to those using sulfonylureas.
- Glucagon-like peptide 1 agonist users showed a 35% lower risk of cardiovascular events relative to sulfonylurea users.
- Serious adverse events were rare across all groups but were lower in users of novel glucose lowering agents compared to sulfonylureas.
- The cohort primarily consisted of patients at low cardiovascular risk, with only 4% having a history of cardiovascular or cerebrovascular events.
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