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Interplay of Glut1 alteration and Alzheimer's disease: A narrative review on glucose transport and energy metabolism
How Changes in Glucose Transport May Relate to Alzheimer's Disease and Brain Energy Use
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Abstract
Reduced GLUT1 expression in Alzheimer's disease brains is associated with impaired cerebral glucose uptake.
- Alzheimer's disease is characterized by progressive cognitive decline and is prevalent in the aging population.
- Traditional models of Alzheimer's disease pathogenesis have failed to provide definitive therapeutic breakthroughs.
- Emerging research indicates that metabolic dysfunction, particularly in glucose transport, may play a central role in the progression of Alzheimer's disease.
- GLUT1 is essential for glucose transport across the blood-brain barrier and maintaining brain energy metabolism.
- Alterations in GLUT1 expression are linked to neuronal dysfunction and neurodegeneration in Alzheimer's disease.
- Potential therapeutic strategies to restore GLUT1 function include gene therapy, ketogenic diets, and small molecules that enhance GLUT1 expression.
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