Glutathione S-Transferase M1, GSTT1 and GSTP1 Genetic Polymorphisms and the Risk of Age-Related Macular Degeneration

Published Jan 8, 2011Ophthalmic research

Genetic Differences in Antioxidant Enzymes and the Risk of Age-Related Macular Degeneration

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Abstract

The GSTM1-null genotype is significantly associated with an increased risk of developing age-related macular degeneration, with an odds ratio of 1.82.

A total of 120 patients with age-related macular degeneration (AMD) were compared to 198 disease-free controls.
The GSTM1-null genotype was linked to a higher likelihood of dry-type AMD, with an odds ratio of 1.98.
In a regression analysis, only the GSTM1-null genotype showed a significant relationship with the development of AMD.
No significant associations were found for GSTT1 and GSTP1 polymorphisms in relation to AMD risk.

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PURPOSE: To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD).

PATIENTS AND METHODS: This case-control study included a total of 120 patients with AMD (65 with dry-type AMD and 55 with wet-type AMD) and 198 disease-free controls. GSTM1 and GSTT1 polymorphisms were analyzed by using a multiplex polymerase chain reaction (PCR), and GSTP1 polymorphism was detected by real-time PCR assay.

RESULTS: GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.82, 95% CI = 1.14-2.91). Stratification by AMD subtypes revealed a significant relationship between GSTM1-null genotype and dry-type AMD (p = 0.02, OR = 1.98, 95% CI = 1.10-3.53). In a stepwise regression model, only GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.77, 95% CI = 1.11-2.81).

CONCLUSIONS: Our findings suggest that genetic polymorphisms of GST may have a role in the development of AMD.

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Glutathione S-Transferase M1, GSTT1 and GSTP1 Genetic Polymorphisms and the Risk of Age-Related Macular Degeneration

Abstract

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