Interaction Between the Glymphatic System and α-Synuclein in Parkinson’s Disease

Glymphatic suppression via aquaporin-4 (AQP4) gene deletion or acetazolamide treatment reduced the clearance of injected α-synuclein in mice.

• The glymphatic system is involved in clearing α-synuclein from the brain.
• AQP4 deficiency in mice accelerated the accumulation of α-synuclein and contributed to the loss of dopaminergic neurons.
• Mice overexpressing human A53T-α-synuclein showed reduced AQP4 expression and impaired glymphatic activity.
• The findings suggest a link between glymphatic function and α-synuclein pathology in Parkinson's disease.
• Restoring glymphatic activity may offer a potential therapeutic target to delay progression of Parkinson's disease.

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