Full text is available at the source.
Abstract
Breakdowns and dysfunction of the glymphatic system and meningeal lymphatics are crucial in age-related brain changes and neurodegenerative diseases.
- The glymphatic system is involved in removing metabolic waste from the brain.
- Meningeal lymphatics may serve as a drainage route for cerebrospinal fluid to the bloodstream.
- Both systems are linked to inflammatory responses and immune surveillance in the central nervous system.
- Dysfunction in these systems is associated with brain injuries, tumors, and neurodegenerative disease pathogenesis.
- Factors such as aging, medications, sleep patterns, genetics, and body posture may influence the brain's drainage system.
Simplified