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Abstract
Granzyme K (GzmK) deficiency markedly attenuated organ aging in aged mice.
- GzmK is significantly upregulated in aged memory CD8+ T cells.
- Despite ongoing immune aging, GzmK deficiency does not affect T cell dysfunction.
- GzmK plays a critical role in age-related tissue decline, uncoupling immune and tissue aging.
- In the kidney, GzmK deficiency is linked to reduced complement deposition.
- In the liver, improved function and reduced fibrosis occur independently of complement, associated with increased decorin and decreased pro-fibrotic TGF-β signaling.
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