Chemical record (New York, N.Y.)Jan 13, 2025

Environmentally Friendly Creation and Biological Study of Seven-Membered Azepine Compounds: Recent Advances

Alzheimers & Treatments Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 5, 2026

Abstract

Azepine-based compounds exhibit diverse biological activities including anticancer and antibacterial effects.

Recent advances in the synthesis of azepine derivatives include eco-friendly methodologies that support green chemistry principles.
Azepine derivatives may demonstrate a range of biological activities, such as anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, and neuroprotective effects.
Molecular docking studies and structure-activity relationships (SAR) are discussed to understand the interactions and effectiveness of azepine compounds.
Preclinical and clinical trials provide insights into the modes of action of these compounds.

Simplified

Seven-membered nitrogen-containing heterocycles, particularly azepine-based compounds, represent an intriguing class of molecules with vast arrays of applications. These compounds have garnered considerable attention in synthetic and medicinal chemistry due to their non-planar, non-aromatic features, which offer structural flexibility and diversity to design new drugs with improved pharmacological properties. This review summarizes the recent advances in the synthesis of azepine derivatives, including eco-friendly methodologies that align with the principles of green chemistry, which emphasize atom economy, sustainability, and waste reduction. Besides, the present article highlights diverse biological activities, viz. anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, and neuroprotective effects of azepine derivatives. Additionally, the review discusses key aspects such as molecular docking studies, structure-activity relationships (SAR), and mode of action evident through preclinical and clinical trials. The information presented in the current review article would assist researchers in designing and developing novel azepine-based leads for varied therapeutic applications.

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Environmentally Friendly Creation and Biological Study of Seven-Membered Azepine Compounds: Recent Advances

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