Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise

Mice with GHR deletion in LepR cells showed increased aerobic performance after 8 weeks of treadmill training.

• GHR ablation in LepR-expressing neurons is associated with reduced fat mass and increased muscle size and energy expenditure.
• Deletion of GHR in SF1-expressing neurons prevents improvements in running capacity and is associated with increased fat mass.
• Trained mice with GHR deletion in SF1 cells exhibited a reduction in muscle size compared to controls.
• Glycemia levels were altered by GHR ablation before and after maximum running tests, although glucose tolerance was not significantly affected.
• GHR signaling in hypothalamic neurons may regulate the capacity to adapt to aerobic exercise in a cell-specific manner.

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