Full text is available at the source.
Abstract
Sarcopenic obesity may be influenced by gut microbiota dysbiosis, which is associated with changes in muscle-lipid homeostasis.
- Gut microbiota plays a multifactorial role in the pathogenesis of sarcopenic obesity.
- A Western diet and sedentary lifestyle can alter gut microbiota composition.
- These dietary and lifestyle changes may lead to reduced short-chain fatty acids and increased lipopolysaccharides.
- Alterations in gut microbiota are linked to systemic inflammation and metabolic dysfunction in adipose tissue and skeletal muscle.
- Emerging interventions, such as probiotics and glucagon-like peptide-1 receptor agonists, show potential for therapeutic applications.
- Personalized strategies combining microbiota modulation, dietary optimization, and exercise could help counteract sarcopenic obesity.
Simplified