We can’t show the full text here under this license. Use the link below to read it at the source.
Prenatal depression-associated gut microbiota induces depressive-like behaviors and hippocampal neuroinflammation in germ-free mice
Gut bacteria linked to prenatal depression cause depression-like behavior and brain inflammation in mice without microbes
AI simplified
Abstract
Fecal microbiota from women with prenatal depression induced significant changes in germ-free mice, including altered gut bacteria and increased neuroinflammation.
- Mice receiving (FMT) from women with prenatal depression exhibited decreased levels of Ligilactobacillus and increased levels of Akkermansia.
- Altered glycerophospholipid metabolism was observed in mice after FMT from women with prenatal depression.
- Plasma lipopolysaccharide (LPS) levels significantly increased in mice that received FMT, indicating potential systemic inflammation.
- Proliferation of microglia in the hippocampus was significant in mice receiving FMT, suggesting neuroinflammatory responses.
- Expression levels of nuclear factor-κB (NF-κB) p65, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) mRNA were significantly elevated in FMT mice, indicating active neuroinflammation.
- Dysbiosis of gut microbiota is associated with depressive-like behaviors and may play a causal role in the development of prenatal depression.
AI simplified
Key numbers
17×
Increase in Akkermansia
Relative abundance of Akkermansia in the gut microbiota of recipient mice.
17×
Decrease in Ligilactobacillus
Relative abundance of Ligilactobacillus in the gut microbiota of recipient mice.
17×
Increase in plasma
Plasma concentrations in recipient mice.