Full text is available at the source.
Abstract
Disruption of gut microbial balance, known as dysbiosis, is associated with increased amyloid-beta deposition and tau hyperphosphorylation, key features of Alzheimer's disease.
- Gut microbiota play a critical role in immune regulation and metabolic activity linked to brain function.
- Dysbiosis is connected to oxidative stress, neuroinflammation, and impaired neurotransmission in the context of Alzheimer's disease.
- Microbial metabolites can influence the permeability of the blood-brain barrier and affect neuroimmune responses.
- Emerging evidence suggests gut microbiota may contribute to early onset and progression of Alzheimer's through systemic inflammation.
- Therapeutic strategies aimed at modulating the gut microbiome may help restore balance and mitigate cognitive decline in Alzheimer's disease.
Simplified