The gut-brain axis and cognitive control: A role for the vagus nerve

Feb 21, 2023Seminars in cell & developmental biology

How the gut-brain connection and the vagus nerve may influence thinking and self-control

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Abstract

Recent findings suggest that vagus nerve signaling from the gut may influence neurocognitive functions such as anxiety, depression, and memory.

  • Vagus nerve acts as a relay between the gut and brain, transmitting metabolic signals.
  • Gut-derived vagal signaling may help alleviate anxiety and depressive-like states.
  • Increased vagal activity is associated with enhanced motivation and memory functions.
  • Meal consumption could trigger vagal signaling that aids in encoding meal-related memories.
  • Transcutaneous vagus nerve stimulation may be a potential treatment for anxiety disorders, major depressive disorder, and dementia-related memory issues.

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