CNS & neurological disorders drug targetsSep 11, 2026

Gut Microbes' Role in Alzheimer's Disease Development and Treatment

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗

Updated Sep 12, 2026

Abstract

Alzheimer's disease is characterized by amyloid-β accumulation, tau hyperphosphorylation, and cognitive decline.

The gut-brain axis may play a critical role in the development of Alzheimer's disease.
Evidence suggests that immune, metabolic, and neuroendocrine pathways are involved in this relationship.
Understanding these connections could provide insights into the mechanisms of Alzheimer's disease.

Simplified

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, and cognitive decline. Increasing evidence implicates the gut-brain axis as a key regulator of AD pathogenesis through immune, metabolic, and neuroendocrine pathways.

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