The article frames IBD-related coagulation problems as part of a gut-brain inflammation-neuro-coagulation network that may need multi-omics and AI-guided monitoring.
Evidence
This review or perspective synthesizes concepts around IBD, coagulation, microbiome, metabolism, TF-positive T cells, vagal activity, and AI-assisted biomarker systems.
Caveat
It reports no new patient outcomes, and the abstract says targeted interventions still need rigorous randomized trials and better mechanistic characterization.
Simplified
Inflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, metabolomics, and single-cell transcriptomics-are essential to construct dynamic models that monitor coagulation, microbiome, and metabolism for precise assessment of disease activity and thrombotic or bleeding risks. Interventions targeting gut-brain axis nodes, such as eliminating tissue factor-positive (TF⁺) T cells or modulating vagal activity, show potential to disrupt the inflammation-coagulation cycle, although rigorous randomized trials are still needed. Artificial intelligence (AI)-assisted systems that integrate real-time biomarker monitoring with multi-omics predictions represent a novel paradigm for managing IBD-related coagulation dysfunction. Key challenges include elucidating gut-brain-liver axis regulation of coagulation and characterizing platelet functional heterogeneity. Future efforts must prioritize ethically compliant multi-omics platforms and racially stratified risk models to advance personalized coagulation management in IBD.
Key numbers
25.2%
Prevalence of Depressive Symptoms
Prevalence of depressive symptoms in IBD patients.
50%
Incidence of Crohn’s Disease-Related Strictures
Incidence of strictures in Crohn’s disease.
2.3×
Thrombin Generation Potential Increase
Increase in thrombin generation potential related to IBD.
Full Text
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