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Gut-Brain Axis Dysregulation in Inflammatory Bowel Disease: Implications for Coagulation Abnormalities and Extraintestinal Manifestations
Gut-Brain Communication Problems in Inflammatory Bowel Disease Linked to Blood Clotting Issues and Symptoms Outside the Gut
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Abstract
Integrated multi-omics analyses are essential to monitor disease activity and thrombotic risks in inflammatory bowel disease (IBD).
- IBD is characterized by chronic intestinal inflammation linked to an imbalance in the .
- Current staging systems do not adequately capture the complex interactions within the inflammation-neuro-coagulation triad.
- Targeting specific components of the gut-brain axis may disrupt the cycle of inflammation and coagulation.
- AI-assisted systems could provide innovative approaches for managing coagulation dysfunction in IBD by integrating real-time biomarker monitoring.
- Challenges include understanding the regulation of coagulation across the gut-brain-liver axis and the variability of platelet function.
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Key numbers
25.2%
Prevalence of Depressive Symptoms
Prevalence of depressive symptoms in IBD patients.
50%
Incidence of Crohn’s Disease-Related Strictures
Incidence of strictures in Crohn’s disease.
2.3×
Thrombin Generation Potential Increase
Increase in thrombin generation potential related to IBD.