Gut-brain connection problems, gut lining damage, and body-wide inflammation linked to thinking problems after gallbladder surgery

Postoperative cognitive dysfunction (POCD) is a common complication following cholecystectomy.

• The gut-brain axis may be critical in the development of POCD.
• Intestinal barrier dysfunction could contribute to systemic inflammation.
• Systemic inflammation is associated with cognitive impairment in patients.
• The specific relationships linking these factors have not been quantitatively characterized in this patient population.

Simplified