How Imbalance in Gut Bacteria May Be Linked to Stroke through Gut-Brain Communication

Gut dysbiosis may precede and worsen stroke severity while also being induced by stroke itself.

• Gut microbiota influences immune, metabolic, and neuroinflammatory processes through the gut-brain axis.
• Microbiota-derived metabolites can affect the activation states of immune cells in the brain, impacting neuroinflammation and tissue repair.
• The role of border-associated macrophages, especially perivascular macrophages, in maintaining blood-brain barrier integrity is underexplored.
• Dietary patterns significantly affect gut microbiota composition, which in turn may influence immune responses in the central nervous system.
• These findings suggest potential for diet- and microbiota-targeted interventions as therapeutic strategies in stroke.

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