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Abstract
Gut microbiota may influence immune responses in gliomas, particularly glioblastomas.
- The tumor microenvironment in gliomas is highly immunosuppressive, complicating treatment efforts.
- Emerging evidence indicates that gut microbiota could shape both systemic and central immune responses.
- Microbial metabolites and immune cell modulation are associated with changes in microglial activation and T cell infiltration.
- Responses to immune checkpoint inhibitors, including PD-1 and other emerging targets, may be influenced by gut-derived factors.
- The effectiveness of CAR-T and CAR-NK therapies could be affected by the composition of gut microbiota.
- Strategies like probiotics, engineered microbes, or may enhance the effectiveness of immunotherapy.
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