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Modeling gut inflammation using intestinal organoids: Advances, challenges, and future perspectives
Using lab-grown intestinal tissue to study gut inflammation: progress, challenges, and future directions
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Abstract
Intestinal organoids derived from adult stem cells or patient-specific induced pluripotent stem cells may effectively model gut inflammation.
- These three-dimensional structures replicate key intestinal features such as crypt-villus architecture and cellular diversity.
- Modeling gut inflammation through cytokine stimulation and co-culture with immune cells has provided insights into epithelial barrier dysfunction.
- There is evidence of immune-epithelial crosstalk and disease-specific responses in inflammatory bowel disease using these organoids.
- Innovations like gene-editing technologies and organoid-on-chip systems have enhanced the research capabilities of intestinal organoids.
- Challenges remain in achieving long-term immune co-culture and standardized readouts for these models.
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