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Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells
Gut microbes may boost colon serotonin by helping gut cells respond to short-chain fatty acids
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Abstract
5-HT concentrations were significantly higher in humanized (HM) and conventionally raised (CR) mice compared to germ-free (GF) mice, with levels of 25 ± 2 ng/mg and 35 ± 3 ng/mg respectively.
- Gut microbiota from HM and conventionally raised mice increased colonic mRNAs related to serotonin synthesis, specifically Tph1 and chromogranin A.
- 5-HT reduced the duration of colonic contractions in both GF and HM mice.
- There was no effect of microbiota on the expression of genes involved in serotonin breakdown or receptor activity.
- Microbiota influenced the production of short-chain fatty acids, which promoted serotonin production in human enterochromaffin cell models.
- Enterochromaffin cell numbers remained unchanged despite increased serotonin levels.
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