Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients

Mar 22, 2021Journal of microbiology and biotechnology

Changes in Gut Bacteria and Their Predicted Functions in People with Chronic Hives

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Abstract

CSU patients showed significant increases in the relative abundance of Proteobacteria, Bacilli, Enterobacterales, and Enterobacteriaceae compared to healthy controls.

Chronic spontaneous urticaria (CSU) is a condition linked to both allergy and autoimmunity.
The gut microbiota of CSU patients displayed dysbiosis when compared to healthy individuals.
Dominant bacterial groups in CSU patients included Firmicutes, Bacteroidetes, Proteobacteria, and Verrucomicrobia.
Abnormal gastrointestinal function pathways related to transport and metabolism were predicted based on the microbiota composition.
Findings suggest that specific bacterial taxa increased in CSU patients may play a role in its development.

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The effects of the gut microbiome on both allergy and autoimmunity in dermatological diseases have been indicated in several recent studies. Chronic spontaneous urticaria (CSU) is a disease involving allergy and autoimmunity, and there is no report detailing the role of microbiota alterations in its development. This study was performed to identify the fecal microbial composition of CSU patients and investigate the different compositions and potential genetic functions on the fecal microbiota between CSU patients and normal controls. The gut microbiota of CSU patients and healthy individuals were obtained by 16s rRNA massive sequencing. Gut microbiota diversity and composition were compared, and bioinformatics analysis of the differences was performed. The gut microbiota composition results showed that Firmicutes, Bacteroidetes, Proteobacteria, and Verrucomicrobia were dominant microbiota in CSU patients. The differential analysis showed that relative abundance of the Proteobacteria (= 0.03), Bacilli (= 0.04), Enterobacterales (= 0.03), Enterobacteriaceae (= 0.03) was significantly increased in CSU patients. In contrast, the relative abundance of, and(all< 0.05) in these patients significantly decreased compared with healthy controls. The different microbiological compositions impacted normal gastrointestinal functions based on function prediction, resulting in abnormal pathways, including transport and metabolism. We found CSU patients exhibited gut microbiota dysbiosis compared with healthy controls. Our results indicated CSU is associated with gut microbiota dysbiosis and pointed out that the bacterial taxa increased in CSU patients, which might be involved in the pathogenesis of CSU. These results provided clues for future microbial-based therapies on CSU. p p p p Megamonas, Megasphaera Dialister p

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Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients

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