Neurodegenerative disease managementOct 21, 2025

Differences in gut bacteria of Parkinson’s disease patients in Central Kerala

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 1, 2026

Abstract

Seven microbial species are associated with differences in gut microbiota diversity between Parkinson's disease patients and their controls.

Significant differences in beta diversity were observed between Parkinson's disease patients and their control group (p = 0.007).
Network analysis indicated specific microbial communities were enhanced in either the Parkinson's group or the control group.
The findings suggest potential alterations in gut microbiota composition in individuals with Parkinson's disease.
The study provides preliminary evidence for gut microbiome changes related to Parkinson's disease in a specific population.

Simplified

BACKGROUND AND OBJECTIVES: Gut microbiota dysbiosis is increasingly implicated in Parkinson's disease (PD). This study aimed to find gut microbiota diversity and composition of PD patients in Central Kerala population, India.

METHODS: 16 PD patients were enrolled and their spouse formed the controls. Fecal Microbiome analysis was performed by 16S rRNA amplicon sequencing.

RESULTS: Seven microbial species significantly contributed to the differences in beta diversity between the PD and control groups ( = 0.007). On network analysis,,andrepresented the PD group communities andandrepresented the controls.andenhanced centrality in the spouse control network and,, andin PD group. p Bifidobacterium longum Bacteroides fragilis Blautia obeum Roseburia faecis Ruminococcus bromii Ruminococcus gnavus Faecalibacterium prausnitzii Ruminococcus gnavus Bifidobacterium longum Eubacterium biforme Roseburia faecis

CONCLUSIONS: This study offers initial evidence for identifying PD associated gut microbiome alterations in the Kerala population to be further explored with larger and more detailed longitudinal study.

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Competing interests

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PubMed

Differences in gut bacteria of Parkinson’s disease patients in Central Kerala

Abstract

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Funding

Competing interests

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Abstract

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