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Changes in the gut microbiome of patients with esophageal cancer: A systematic review and meta-analysis based on 16S gene sequencing technology
Changes in gut bacteria in patients with esophageal cancer based on gene sequencing studies
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Abstract
In a meta-analysis of 10 studies involving 527 individuals, significant differences in gut microbiota were observed between esophageal cancer patients and healthy controls.
- The Chao1 index was significantly higher in esophageal cancer patients (46.01) compared to healthy controls (42.67).
- The Shannon index (14.90 vs. 19.05), ACE (39.24 vs. 58.47), and observed operational taxonomic units (OTUs) (28.93 vs. 70.10) were significantly lower in esophageal cancer patients.
- The abundance of the phylum Bacteroidetes increased in esophageal cancer patients (37.89) compared to healthy controls (32.77), while Firmicutes decreased (37.63 vs. 38.72).
- At the genus/family level, significant reductions were found in Bacteroidaceae, Prevotellaceae, and Streptococcaceae, while Veillonellaceae increased.
- Changes in gut microbiota in esophageal cancer patients were identified, but the conclusions were inconsistent.
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