Current neuropharmacology

How Pollution-Related Changes in Gut Bacteria May Affect Mental Health Through the Gut-Brain Link

Updated

Abstract

Environmental pollutants are linked to changes in the gut microbiome.

  • Pollutants can disrupt the balance of gut bacteria, leading to dysbiosis.
  • This disruption may affect the microbiota-gut-brain communication pathways.
  • Alterations in microbial metabolites could contribute to neurodevelopment and behavior changes.
  • Evidence suggests associations between exposure to pollutants and cognitive or mental health issues.
  • Current understanding of these mechanisms is based on human studies and animal models.
  • Further investigation is needed to clarify the quantitative relationships between microbiome changes and neurobehavioral effects.

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