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Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
Changes in gut bacteria may cause depression-like behavior through the body's metabolism
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Abstract
The absence of gut microbiota in germ-free mice resulted in decreased immobility time in the forced swimming test.
- Major depressive disorder (MDD) is associated with significant differences in gut microbiota composition compared to healthy individuals.
- MDD patients exhibit changes in the relative abundance of specific gut bacteria, including Firmicutes, Actinobacteria, and Bacteroidetes.
- Fecal microbiota transplantation from MDD patients to germ-free mice induced depression-like behaviors.
- Mice receiving 'depression microbiota' showed disturbances in microbial genes and host metabolites linked to carbohydrate and amino acid metabolism.
- Dysbiosis of the gut microbiome may play a causal role in developing depressive-like behaviors.
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