Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

Mar 15, 2021Pituitary

Gut bacteria in patients newly diagnosed with acromegaly

AI simplified

Gut-Brain Axis on OpenScience ↗PubMed ↗DOI ↗

Abstract

Patients with newly diagnosed acromegaly showed significantly lower bacterial diversity in their gut microbiota.

The analysis involved stool samples from seven patients with a mean age of 48 ± 17.6 years.
A predominance of the Bacteroidetes phylum was observed in the patient group.
The ratio of Firmicutes to Bacteroidetes was significantly altered in patients with acromegaly.
In healthy controls, Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominant.
These findings suggest a significant alteration in gut microbiota associated with newly diagnosed acromegaly.

AI simplified

PURPOSE: Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.

METHOD: Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.

RESULTS: Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group.

CONCLUSION: The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the gut-brain axis brief